Auditory Resilience

만성적인 소음 및 스트레스는 달팽이관 세포에 산화 스트레스를 가해 청각 회복력을 저하시키고, 이는 염증 노화를 통한 전신 면역 회복력 저하의 경로입니다. 디지털 환경 사용자의 청력 및 염증 지표를 분석하고, AI 기반 맞춤형 소음 관리/영양 루틴 개입의 효과를 검증하는 것입니다. 최종 목표는 루틴 개입을 통해 청각 시스템의 회복력을 향상시키고, 이로 인해 청각 노화 및 전신 면역 노화 지표들이 개선되는 효과를 검증하는 데 있습니다. 

 To analyze individual noise exposure and hearing data to develop and validate an AI-based customized noise/nutrition routine framework that enhances Auditory Resilience and prevents hearing loss. Scientific Contribution: To establish a new healthcare standard by demonstrating the regulatory effect of digital routines on the Gut-Auditory Axis and Neuroinflammation, contributing to the prevention of presbycusis (age-related hearing loss) and tinnitus. Application: This model can be applied to provide customized hearing protection, nutrition, and rest routine solutions for users at risk of noise-induced hearing loss or suffering from chronic tinnitus. 

 The routine centers on cochlear cell protection through Minimizing Noise Exposure, Safe Headphone Use, and Antioxidant Nutritional Enhancement. Specific Routines: Regular Auditory Rest routines and an anti-inflammatory/antioxidant diet mitigate oxidative stress in the auditory system, contributing to enhanced Auditory Resilience. Duration & Evaluation: Positive changes in hearing threshold shift, tinnitus severity, and inflammatory markers will be evaluated over a 12-week digital routine intervention. 

 Adhere strictly to Personal Data Protection regulations when collecting sensitive data (e.g., hearing test results), ensuring routine suggestions are unbiased across diverse ages/noise exposure environments. Transparency: Enhance Explainability (XAI) by clearly detailing the basis for the AI's noise management/nutrition recommendations to secure user trust. Access/Safety: The routine is a wellness approach (not treatment); a safety protocol requires immediate cessation and mandatory consultation with a medical professional upon signs of hearing deterioration. 

1.Research progress in modulating the auditory system by the cochlear circadian clock system in response to noise exposure2025링크2.Disrupted Circadian Rhythms Exacerbate Inner Ear Damage in a Murine Endolymphatic Hydrops Model2024링크3.The role of the circadian timing system in sarcopenia in old age: a scoping review (Focus on systemic aging link)2025링크4.Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions2024링크5.Constant Light Dysregulates Cochlear Circadian Clock and Exacerbates Noise-Induced Hearing Loss2020링크

1.Association of age-related hearing loss with cognitive impairment and dementia: an umbrella review2023링크2.Hearing Loss and Cognitive Decline in the Aging Population: Emerging Perspectives in Audiology2024링크3.Age-Related Hearing Loss Is Accompanied by Chronic Inflammation in the Cochlea and the Cochlear Nucleus2022링크4.Central Auditory Functions of Alzheimer's Disease and Its Preclinical Stages: A Systematic Review and Meta-Analysis2022링크5.Hearing Impairment and Cognition in an Aging World2021링크

1. | The Role of Mitochondria and Oxidative Stress in Age-Related Macular Degeneration and Other Ocular Diseases | 2024 | 링크
2. | Blue Light Exposure and Its Effects on Ocular Surface, Retina, and Circadian Rhythm: A Systematic Review | 2024 | 링크
3. | Digital Eye Strain: Mechanisms and Evidence-Based Interventions for Vision and Ocular Health | 2023 | 링크
4. | Nutritional strategies to protect the aging eye: Focusing on Lutein, Zeaxanthin, and Omega-3 Fatty Acids | 2023 | 링크
5. | Visual-Cognitive Integration: The Role of Aging and Attentional Load in Dual-Task Performance | 2024 | 링크

1.The Role of Lifestyle Factors in Age-Related Hearing Loss: A Narrative Review2024링크2.Inflammaging, the gut-brain axis, and age-related hearing loss: A review of potential links2024링크3.Noise exposure and accelerated hearing aging: A contemporary perspective2023링크4.Nutritional strategies to mitigate age-related hearing loss2023링크5.Psychological Stress and Hearing Health: The Unrecognized Connection2024링크

1.The effect of blue light on skin aging: evidence and mechanisms2024링크2.Oxidative Stress and Inflammation in Skin Aging: A Review of Emerging Therapeutic Strategies2024링크3.Digital Aging: The Impact of Electronic Devices and Blue Light on Skin Health and the Role of Protective Strategies2023링크4.Posture, neck alignment, and their influence on facial aesthetics and aging2023링크5.The role of antioxidants and lifestyle changes in mitigating digital-induced skin damage2023링크

1. | The role of sedentary behavior on muscle health and sarcopenia in older adults | 2024 | 링크
2. | Inflammaging and sarcopenia: mechanisms and therapeutic potential | 2023 | 링크
3. | Exercise as a Strategy to Counteract Immunosenescence and Sarcopenia in Older Adults | 2023 | 링크
4. | Musculoskeletal effects of prolonged sitting in older adults | 2023 | 링크
5. | Physical Activity, Sedentary Behavior, and Their Combined Influence on the Risk of Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis | 2024 | [의심스러운 링크 삭제됨]

1.A review of the auditory-gut-brain axis2023링크2.Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis2024 (Online 2023)링크3.Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study2023링크4.Modulation of Gut Microbiome as a Therapeutic Modality for Auditory Disorders2022링크5.The Link between Gut Dysbiosis Caused by a High-Fat Diet and Hearing Loss2022링크

1. | Sedentary behavior and cardiovascular disease: a narrative review of the mechanisms and evidence | 2023 | 링크
2. | The Implications of Aging on Vascular Health | 2024 | 링크
3. | The Relationship between Daily Screen Time and Hypertension in Children and Adolescents | 2024 | 링크
4. | Impact of Mental Stress on Vascular Function and Cardiovascular Health | 2021 | 링크
5. | The benefits of short bouts of activity on vascular health | 2020 | 링크

1.The 3 I's of immunity and aging: immunosenescence, inflammaging, and immune resilience2024링크2.Reversing the aging immune system: Current approaches and future directions2024링크3.Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies2025링크4.Immunosenescence, inflammaging, and their potential link with the gut-brain axis2023링크5.Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes2025링크